Drug interactions
Metaxalone + Olanzapine
Severity: Moderate
Metaxalone and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is significantly sedating and may add to metaxalone's drowsiness. Dizziness, orthostatic hypotension and falls may be more likely.
What this interaction means in plain words
Metaxalone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Olanzapine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Monitor sedation and orthostatic blood pressure, especially in older patients. Counsel on driving and reduce dose if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Olanzapine
Frequently asked questions
Can I take Metaxalone with Olanzapine?
MediHelp rates the interaction as moderate. Metaxalone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is significantly sedating and may add to metaxalone's drowsiness. Dizziness, orthostatic hypotension and falls may be more likely.
How serious is the interaction between Metaxalone and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, especially in older patients. Counsel on driving and reduce dose if impairment occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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