Drug interactions
Metaxalone + Opium tincture
Severity: Major
Metaxalone and Opium tincture: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture contains morphine, and combining it with metaxalone can add to sedation and slow breathing. The risk is higher with large doses, older age or other depressants.
What this interaction means in plain words
Metaxalone and Opium tincture can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depression from the opioid and the muscle relaxant.
What to do
Use the lowest effective doses for the shortest duration and monitor sedation and respiratory rate. Avoid adding other depressants including alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Opium tincture?
MediHelp rates the interaction as major. Metaxalone and Opium tincture can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opium tincture contains morphine, and combining it with metaxalone can add to sedation and slow breathing. The risk is higher with large doses, older age or other depressants.
How serious is the interaction between Metaxalone and Opium tincture?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor sedation and respiratory rate. Avoid adding other depressants including alcohol.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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