Drug interactions
Metaxalone + Orphenadrine
Severity: Moderate
Metaxalone and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are skeletal muscle relaxants with sedating effects, and orphenadrine also has anticholinergic properties. Together they add drowsiness and dizziness and offer no clear therapeutic gain.
What this interaction means in plain words
Metaxalone and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression, with anticholinergic burden from orphenadrine.
What to do
Avoid using two muscle relaxants at the same time. If they are both used, monitor for oversedation and anticholinergic effects such as confusion or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Orphenadrine?
MediHelp rates the interaction as moderate. Metaxalone and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are skeletal muscle relaxants with sedating effects, and orphenadrine also has anticholinergic properties. Together they add drowsiness and dizziness and offer no clear therapeutic gain.
How serious is the interaction between Metaxalone and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two muscle relaxants at the same time. If they are both used, monitor for oversedation and anticholinergic effects such as confusion or urinary retention.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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