Drug interactions
Metaxalone + Pimozide
Severity: Moderate
Metaxalone and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause CNS depression, so concurrent use may increase drowsiness and reduce alertness. Pimozide has additional cardiac risks of its own, but the interaction with metaxalone is mainly additive sedation.
What this interaction means in plain words
Metaxalone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and impaired coordination, and counsel on avoiding driving. Adjust the dose of metaxalone if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Metaxalone with Pimozide?
MediHelp rates the interaction as moderate. Metaxalone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause CNS depression, so concurrent use may increase drowsiness and reduce alertness. Pimozide has additional cardiac risks of its own, but the interaction with metaxalone is mainly additive sedation.
How serious is the interaction between Metaxalone and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and impaired coordination, and counsel on avoiding driving. Adjust the dose of metaxalone if drowsiness is excessive.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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