Drug interactions
Metaxalone + Protriptyline
Severity: Moderate
Metaxalone and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant that can cause sedation and anticholinergic effects, and metaxalone adds to the drowsiness. Both drugs have serotonergic effects, so serotonin syndrome is a theoretical risk.
What this interaction means in plain words
Metaxalone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and possible additive serotonergic activity.
What to do
Monitor for oversedation and for signs of serotonin toxicity such as agitation, tremor and fever. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Protriptyline?
MediHelp rates the interaction as moderate. Metaxalone and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant that can cause sedation and anticholinergic effects, and metaxalone adds to the drowsiness. Both drugs have serotonergic effects, so serotonin syndrome is a theoretical risk.
How serious is the interaction between Metaxalone and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and for signs of serotonin toxicity such as agitation, tremor and fever. Use the lowest effective doses.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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