Drug interactions
Metaxalone + Quazepam
Severity: Moderate
Metaxalone and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can cause more drowsiness, slower reactions and impaired coordination than either drug alone. This raises the risk of falls and accidents, particularly in older adults.
What this interaction means in plain words
Metaxalone and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from GABA-A potentiation by the benzodiazepine and the sedating effect of metaxalone.
What to do
Use the lowest effective doses and warn the patient about driving and operating machinery. Monitor for excessive sedation, especially in older or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Quazepam?
MediHelp rates the interaction as moderate. Metaxalone and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can cause more drowsiness, slower reactions and impaired coordination than either drug alone. This raises the risk of falls and accidents, particularly in older adults.
How serious is the interaction between Metaxalone and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn the patient about driving and operating machinery. Monitor for excessive sedation, especially in older or frail patients.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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