Drug interactions
Metaxalone + Remifentanil
Severity: Moderate
Metaxalone and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone can increase the sedative and respiratory depressant effects of remifentanil. This may cause excessive drowsiness and impaired breathing.
What this interaction means in plain words
Metaxalone and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Remifentanil?
MediHelp rates the interaction as moderate. Metaxalone and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone can increase the sedative and respiratory depressant effects of remifentanil. This may cause excessive drowsiness and impaired breathing.
How serious is the interaction between Metaxalone and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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