Drug interactions
Metaxalone + Remimazolam
Severity: Major
Metaxalone and Remimazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a benzodiazepine sedative, and metaxalone adds CNS depression. Together they may cause deeper sedation and respiratory depression than expected.
What this interaction means in plain words
Metaxalone and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metaxalone belongs to Musculoskeletal; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation by remimazolam and sedative effects of metaxalone.
What to do
Titrate remimazolam carefully and continuously monitor oxygen saturation, respiration and vital signs during and after the procedure. Ensure resuscitation equipment and trained personnel are available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metaxalone
Other interactions of Remimazolam
Frequently asked questions
Can I take Metaxalone with Remimazolam?
MediHelp rates the interaction as major. Metaxalone and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Remimazolam is a benzodiazepine sedative, and metaxalone adds CNS depression. Together they may cause deeper sedation and respiratory depression than expected.
How serious is the interaction between Metaxalone and Remimazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully and continuously monitor oxygen saturation, respiration and vital signs during and after the procedure. Ensure resuscitation equipment and trained personnel are available.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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