Drug interactions
Metaxalone + Scullcap
Severity: Minor
Metaxalone and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap is used as a traditional calming herb and may add to the drowsiness caused by metaxalone. Evidence on this combination is limited.
What this interaction means in plain words
Metaxalone and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive sedation; the herb's mechanism is not well established.
What to do
Counsel the patient about drowsiness and caution with driving. Stop the herbal product if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metaxalone and Scullcap, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Scullcap?
MediHelp rates the interaction as minor. Metaxalone and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap is used as a traditional calming herb and may add to the drowsiness caused by metaxalone. Evidence on this combination is limited.
How serious is the interaction between Metaxalone and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and caution with driving. Stop the herbal product if excessive sedation occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
