Drug interactions
Metaxalone + Sufentanil sl
Severity: Major
Metaxalone and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with skeletal muscle relaxants can cause profound sedation, hypotension, respiratory depression, coma and death.
What this interaction means in plain words
Metaxalone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through pharmacodynamic synergism.
What to do
Reserve the combination for patients with no adequate alternatives, using the lowest doses for the shortest duration, and monitor for respiratory depression and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Sufentanil sl?
MediHelp rates the interaction as major. Metaxalone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with skeletal muscle relaxants can cause profound sedation, hypotension, respiratory depression, coma and death.
How serious is the interaction between Metaxalone and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with no adequate alternatives, using the lowest doses for the shortest duration, and monitor for respiratory depression and sedation.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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