Drug interactions
Metaxalone + Topiramate
Severity: Moderate
Metaxalone and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone can cause drowsiness and dizziness, and topiramate may cause somnolence and cognitive impairment. Together they may produce greater sedation and impaired psychomotor function.
What this interaction means in plain words
Metaxalone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Advise patients to avoid driving until the response is known and to avoid alcohol. Reduce the metaxalone dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Topiramate
Frequently asked questions
Can I take Metaxalone with Topiramate?
MediHelp rates the interaction as moderate. Metaxalone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone can cause drowsiness and dizziness, and topiramate may cause somnolence and cognitive impairment. Together they may produce greater sedation and impaired psychomotor function.
How serious is the interaction between Metaxalone and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving until the response is known and to avoid alcohol. Reduce the metaxalone dose if sedation is excessive.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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