Drug interactions
Metaxalone + Triazolam
Severity: Moderate
Metaxalone and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining triazolam with metaxalone can produce additive sedation, dizziness, impaired coordination and next-day impairment. Older patients face higher risk of falls and confusion.
What this interaction means in plain words
Metaxalone and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABAergic benzodiazepine action and centrally acting muscle relaxant sedation.
What to do
Use the lowest effective doses and monitor for oversedation. Avoid driving and alcohol, and reduce the triazolam dose in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Triazolam?
MediHelp rates the interaction as moderate. Metaxalone and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining triazolam with metaxalone can produce additive sedation, dizziness, impaired coordination and next-day impairment. Older patients face higher risk of falls and confusion.
How serious is the interaction between Metaxalone and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation. Avoid driving and alcohol, and reduce the triazolam dose in older adults.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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