Drug interactions
Metaxalone + Trifluoperazine
Severity: Moderate
Metaxalone and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine is an antipsychotic with sedative properties, and with metaxalone it can add to drowsiness and dizziness. Impaired psychomotor performance and falls may result.
What this interaction means in plain words
Metaxalone and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor for sedation and orthostatic symptoms, and use the lowest effective doses. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Trifluoperazine?
MediHelp rates the interaction as moderate. Metaxalone and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine is an antipsychotic with sedative properties, and with metaxalone it can add to drowsiness and dizziness. Impaired psychomotor performance and falls may result.
How serious is the interaction between Metaxalone and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, and use the lowest effective doses. Counsel patients to avoid driving and alcohol.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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