Drug interactions
Metformin + Nicardipine
Severity: Minor
Metformin and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can modestly impair glucose tolerance in some patients, which may reduce glycemic control on metformin. Nicardipine may also affect metformin transporter handling, but the clinical impact is small.
What this interaction means in plain words
Metformin and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin belongs to Endocrine; Nicardipine belongs to Cardiovascular.
Why it happens
Possible pharmacodynamic effect on insulin secretion and glucose tolerance, with minor transporter effects.
What to do
Monitor blood glucose when nicardipine is started or stopped. Adjust the metformin dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Nicardipine?
MediHelp rates the interaction as minor. Metformin and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can modestly impair glucose tolerance in some patients, which may reduce glycemic control on metformin. Nicardipine may also affect metformin transporter handling, but the clinical impact is small.
How serious is the interaction between Metformin and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when nicardipine is started or stopped. Adjust the metformin dose if needed.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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