Drug interactions
Metformin + Procarbazine
Severity: Minor
Metformin and Procarbazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibitor activity and has been reported to potentiate hypoglycemic effects of antidiabetic agents. The evidence for a meaningful interaction with metformin is weak.
What this interaction means in plain words
Metformin and Procarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin belongs to Endocrine; Procarbazine belongs to Oncology.
Why it happens
Possible additive glucose lowering through MAO inhibition; mechanism not firmly established.
What to do
Monitor blood glucose when procarbazine is started and adjust the metformin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Metformin with Procarbazine?
MediHelp rates the interaction as minor. Metformin and Procarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Procarbazine has monoamine oxidase inhibitor activity and has been reported to potentiate hypoglycemic effects of antidiabetic agents. The evidence for a meaningful interaction with metformin is weak.
How serious is the interaction between Metformin and Procarbazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when procarbazine is started and adjust the metformin dose if hypoglycemia occurs.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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