Drug interactions
Metformin + Risdiplam
Severity: Moderate
Metformin and Risdiplam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risdiplam inhibits MATE transporters and can raise metformin exposure. Higher levels increase the risk of metformin adverse effects, including lactic acidosis in susceptible patients.
What this interaction means in plain words
Metformin and Risdiplam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin belongs to Endocrine; Risdiplam belongs to Musculoskeletal.
Why it happens
Risdiplam inhibits MATE1 and MATE2-K, reducing renal and biliary excretion of metformin.
What to do
Monitor renal function and glycemic response, and consider reducing the metformin dose, especially in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Risdiplam
- Alogliptin-metformin + Risdiplam Moderate
- Canagliflozin-metformin + Risdiplam Moderate
- Dapagliflozin-metformin + Risdiplam Moderate
- Empagliflozin-metformin + Risdiplam Moderate
- Glyburide-metformin + Risdiplam Moderate
- Linagliptin-metformin + Risdiplam Moderate
Frequently asked questions
Can I take Metformin with Risdiplam?
MediHelp rates the interaction as moderate. Metformin and Risdiplam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risdiplam inhibits MATE transporters and can raise metformin exposure. Higher levels increase the risk of metformin adverse effects, including lactic acidosis in susceptible patients.
How serious is the interaction between Metformin and Risdiplam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glycemic response, and consider reducing the metformin dose, especially in renal impairment.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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