Drug interactions
Linagliptin-metformin + Risdiplam
Severity: Moderate
Linagliptin-metformin and Risdiplam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risdiplam inhibits MATE1 and MATE2-K, which reduces renal tubular secretion of metformin and raises its plasma levels. Higher metformin exposure increases the risk of adverse effects including lactic acidosis.
What this interaction means in plain words
Linagliptin-metformin and Risdiplam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Risdiplam belongs to Musculoskeletal.
Why it happens
Inhibition of renal MATE1 and MATE2-K transporters reduces metformin elimination.
What to do
Monitor glycemic control and renal function, and consider reducing the metformin dose if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Risdiplam
- Alogliptin-metformin + Risdiplam Moderate
- Canagliflozin-metformin + Risdiplam Moderate
- Dapagliflozin-metformin + Risdiplam Moderate
- Empagliflozin-metformin + Risdiplam Moderate
- Glyburide-metformin + Risdiplam Moderate
- Metformin-pioglitazone + Risdiplam Moderate
Frequently asked questions
Can I take Linagliptin-metformin with Risdiplam?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Risdiplam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risdiplam inhibits MATE1 and MATE2-K, which reduces renal tubular secretion of metformin and raises its plasma levels. Higher metformin exposure increases the risk of adverse effects including lactic acidosis.
How serious is the interaction between Linagliptin-metformin and Risdiplam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function, and consider reducing the metformin dose if adverse effects arise.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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