Drug interactions
Empagliflozin-metformin + Risdiplam
Severity: Moderate
Empagliflozin-metformin and Risdiplam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risdiplam inhibits MATE1 and MATE2-K, the renal transporters responsible for metformin secretion, and can increase metformin exposure. Higher levels increase the risk of metformin adverse effects including lactic acidosis, especially with renal impairment.
What this interaction means in plain words
Empagliflozin-metformin and Risdiplam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Risdiplam belongs to Musculoskeletal.
Why it happens
Inhibition of MATE1/MATE2-K reduces renal tubular secretion of metformin.
What to do
Monitor for metformin toxicity and renal function; consider lowering the metformin dose if the combination cannot be avoided. Avoid in patients with significantly reduced eGFR.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Risdiplam
- Alogliptin-metformin + Risdiplam Moderate
- Canagliflozin-metformin + Risdiplam Moderate
- Dapagliflozin-metformin + Risdiplam Moderate
- Glyburide-metformin + Risdiplam Moderate
- Linagliptin-metformin + Risdiplam Moderate
- Metformin-pioglitazone + Risdiplam Moderate
Frequently asked questions
Can I take Empagliflozin-metformin with Risdiplam?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Risdiplam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risdiplam inhibits MATE1 and MATE2-K, the renal transporters responsible for metformin secretion, and can increase metformin exposure. Higher levels increase the risk of metformin adverse effects including lactic acidosis, especially with renal impairment.
How serious is the interaction between Empagliflozin-metformin and Risdiplam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for metformin toxicity and renal function; consider lowering the metformin dose if the combination cannot be avoided. Avoid in patients with significantly reduced eGFR.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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