Drug interactions
Metformin + Tranylcypromine
Severity: Minor
Metformin and Tranylcypromine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can lower blood glucose and may enhance the glucose-lowering effect of antidiabetic agents. Metformin alone seldom causes hypoglycemia, so the effect is usually modest.
What this interaction means in plain words
Metformin and Tranylcypromine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibitors may enhance insulin sensitivity and glucose lowering; the exact mechanism is not well established.
What to do
Monitor blood glucose when starting or stopping the MAO inhibitor and adjust antidiabetic therapy if glucose control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Tranylcypromine?
MediHelp rates the interaction as minor. Metformin and Tranylcypromine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors can lower blood glucose and may enhance the glucose-lowering effect of antidiabetic agents. Metformin alone seldom causes hypoglycemia, so the effect is usually modest.
How serious is the interaction between Metformin and Tranylcypromine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the MAO inhibitor and adjust antidiabetic therapy if glucose control changes.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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