Drug interactions
Metformin + Ziprasidone
Severity: Minor
Metformin and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics can impair glucose tolerance and may reduce the glycemic control achieved with metformin. Ziprasidone carries a lower metabolic risk than many other atypicals, so the effect is generally small.
What this interaction means in plain words
Metformin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-associated insulin resistance and hyperglycemia.
What to do
Monitor fasting glucose and HbA1c periodically and adjust metformin dosing if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Ziprasidone?
MediHelp rates the interaction as minor. Metformin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antipsychotics can impair glucose tolerance and may reduce the glycemic control achieved with metformin. Ziprasidone carries a lower metabolic risk than many other atypicals, so the effect is generally small.
How serious is the interaction between Metformin and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c periodically and adjust metformin dosing if control deteriorates.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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