Drug interactions
Metformin-pioglitazone + Moexipril
Severity: Moderate
Metformin-pioglitazone and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally enhance the glucose-lowering effect of antidiabetic drugs, leading to hypoglycemia. ACE inhibitor-related renal impairment may also reduce metformin clearance and increase lactic acidosis risk.
What this interaction means in plain words
Metformin-pioglitazone and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Moexipril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity via increased bradykinin, and renal function changes can reduce metformin elimination.
What to do
Monitor blood glucose and renal function, especially after starting or increasing the ACE inhibitor. Reassess metformin dosing if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Metformin-pioglitazone with Moexipril?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally enhance the glucose-lowering effect of antidiabetic drugs, leading to hypoglycemia. ACE inhibitor-related renal impairment may also reduce metformin clearance and increase lactic acidosis risk.
How serious is the interaction between Metformin-pioglitazone and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, especially after starting or increasing the ACE inhibitor. Reassess metformin dosing if renal function declines.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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