Drug interactions
Metformin-pioglitazone + Nilotinib
Severity: Moderate
Metformin-pioglitazone and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib commonly causes hyperglycemia, which may reduce glycemic control in diabetic patients. Nilotinib also inhibits CYP2C8 in vitro, which could raise pioglitazone exposure, although the clinical relevance is uncertain.
What this interaction means in plain words
Metformin-pioglitazone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Nilotinib has direct hyperglycemic effects through an incompletely understood mechanism and may inhibit CYP2C8-mediated pioglitazone metabolism.
What to do
Monitor fasting glucose and HbA1c regularly during nilotinib therapy and intensify antidiabetic treatment if needed. Watch for fluid retention if pioglitazone effects appear increased.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Metformin-pioglitazone with Nilotinib?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib commonly causes hyperglycemia, which may reduce glycemic control in diabetic patients. Nilotinib also inhibits CYP2C8 in vitro, which could raise pioglitazone exposure, although the clinical relevance is uncertain.
How serious is the interaction between Metformin-pioglitazone and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c regularly during nilotinib therapy and intensify antidiabetic treatment if needed. Watch for fluid retention if pioglitazone effects appear increased.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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