Drug interactions
Metformin-pioglitazone + Phenelzine
Severity: Moderate
Metformin-pioglitazone and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors such as phenelzine can enhance the glucose-lowering effect of antidiabetic drugs and may cause hypoglycemia. Patients taking metformin-pioglitazone may need closer glucose monitoring.
What this interaction means in plain words
Metformin-pioglitazone and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibitors may increase insulin sensitivity and secretion, producing additive hypoglycemic effects.
What to do
Monitor blood glucose when phenelzine is started, stopped or adjusted and reduce antidiabetic dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Metformin-pioglitazone with Phenelzine?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors such as phenelzine can enhance the glucose-lowering effect of antidiabetic drugs and may cause hypoglycemia. Patients taking metformin-pioglitazone may need closer glucose monitoring.
How serious is the interaction between Metformin-pioglitazone and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when phenelzine is started, stopped or adjusted and reduce antidiabetic dose if hypoglycemia occurs.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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