Drug interactions
Metformin-pioglitazone + Promethazine
Severity: Minor
Metformin-pioglitazone and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine, a phenothiazine antihistamine, can cause mild hyperglycemia and weaken glycemic control. Clinically significant effects are uncommon with short courses.
What this interaction means in plain words
Metformin-pioglitazone and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-pioglitazone belongs to Endocrine; Promethazine belongs to Respiratory.
Why it happens
Phenothiazine-related reduction in insulin release and sensitivity opposes antidiabetic therapy.
What to do
Monitor blood glucose with prolonged promethazine use and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Metformin-pioglitazone with Promethazine?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine, a phenothiazine antihistamine, can cause mild hyperglycemia and weaken glycemic control. Clinically significant effects are uncommon with short courses.
How serious is the interaction between Metformin-pioglitazone and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose with prolonged promethazine use and adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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