Drug interactions
Metformin-pioglitazone + Rasagiline
Severity: Minor
Metformin-pioglitazone and Rasagiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may enhance glucose lowering in patients taking antidiabetic drugs. Evidence for rasagiline is limited and any effect is likely small.
What this interaction means in plain words
Metformin-pioglitazone and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-pioglitazone belongs to Endocrine; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition may modestly improve insulin sensitivity; the mechanism is not well established.
What to do
Monitor blood glucose when rasagiline is started and adjust antidiabetic therapy if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Metformin-pioglitazone with Rasagiline?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors may enhance glucose lowering in patients taking antidiabetic drugs. Evidence for rasagiline is limited and any effect is likely small.
How serious is the interaction between Metformin-pioglitazone and Rasagiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when rasagiline is started and adjust antidiabetic therapy if hypoglycemia occurs.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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