Drug interactions
Metformin-pioglitazone + Vandetanib
Severity: Moderate
Metformin-pioglitazone and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib can reduce the renal tubular uptake of metformin, which may raise metformin plasma concentrations. Higher exposure increases the risk of gastrointestinal intolerance and, in susceptible patients, lactic acidosis.
What this interaction means in plain words
Metformin-pioglitazone and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Vandetanib belongs to Oncology.
Why it happens
Vandetanib inhibits organic cation transporter 2 (OCT2), decreasing renal secretion of metformin.
What to do
Monitor renal function and for signs of metformin toxicity such as GI upset or lactic acidosis. Consider reducing the metformin dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Metformin-pioglitazone with Vandetanib?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib can reduce the renal tubular uptake of metformin, which may raise metformin plasma concentrations. Higher exposure increases the risk of gastrointestinal intolerance and, in susceptible patients, lactic acidosis.
How serious is the interaction between Metformin-pioglitazone and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for signs of metformin toxicity such as GI upset or lactic acidosis. Consider reducing the metformin dose if adverse effects appear.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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