Drug interactions
Metformin-repaglinide + Nelfinavir
Severity: Moderate
Metformin-repaglinide and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors, including nelfinavir, are associated with insulin resistance and hyperglycemia, which may reduce the effectiveness of antidiabetic therapy. Nelfinavir also inhibits CYP3A4 and may modestly raise repaglinide levels.
What this interaction means in plain words
Metformin-repaglinide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance antagonizes antidiabetic effects, and CYP3A4 inhibition may reduce repaglinide clearance.
What to do
Monitor blood glucose and HbA1c and adjust antidiabetic doses as needed. Watch for hypoglycemia with repaglinide as well as for loss of control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Nelfinavir?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors, including nelfinavir, are associated with insulin resistance and hyperglycemia, which may reduce the effectiveness of antidiabetic therapy. Nelfinavir also inhibits CYP3A4 and may modestly raise repaglinide levels.
How serious is the interaction between Metformin-repaglinide and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and adjust antidiabetic doses as needed. Watch for hypoglycemia with repaglinide as well as for loss of control.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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