Drug interactions
Metformin-repaglinide + Niacin
Severity: Moderate
Metformin-repaglinide and Niacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Niacin at lipid-lowering doses can raise blood glucose and worsen insulin resistance. This may weaken the control achieved with metformin and repaglinide and require changes in antidiabetic therapy.
What this interaction means in plain words
Metformin-repaglinide and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Niacin belongs to Cardiovascular.
Why it happens
Niacin impairs insulin sensitivity and increases hepatic glucose output, opposing the effect of antidiabetic drugs.
What to do
Monitor blood glucose and HbA1c when niacin is started or its dose increased, and adjust antidiabetic doses. Watch for hypoglycemia when niacin is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Niacin
- Alogliptin-metformin + Niacin Moderate
- Atorvastatin + Niacin Moderate
- Canagliflozin-metformin + Niacin Moderate
- Cholestyramine + Niacin Moderate
- Colestipol + Niacin Moderate
- Dapagliflozin-metformin + Niacin Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Niacin?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Niacin at lipid-lowering doses can raise blood glucose and worsen insulin resistance. This may weaken the control achieved with metformin and repaglinide and require changes in antidiabetic therapy.
How serious is the interaction between Metformin-repaglinide and Niacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when niacin is started or its dose increased, and adjust antidiabetic doses. Watch for hypoglycemia when niacin is withdrawn.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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