Drug interactions
Metformin-repaglinide + Nilotinib
Severity: Moderate
Metformin-repaglinide and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is associated with hyperglycemia, which may reduce the effectiveness of antidiabetic therapy. It also inhibits CYP3A4 and CYP2C8, which could raise repaglinide levels and increase the risk of hypoglycemia.
What this interaction means in plain words
Metformin-repaglinide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4 and CYP2C8 (raising repaglinide exposure) and has independent hyperglycemic effects.
What to do
Monitor blood glucose frequently after starting nilotinib and adjust the repaglinide and metformin doses. Nilotinib also prolongs the QT interval, so review other QT-active drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Nilotinib?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is associated with hyperglycemia, which may reduce the effectiveness of antidiabetic therapy. It also inhibits CYP3A4 and CYP2C8, which could raise repaglinide levels and increase the risk of hypoglycemia.
How serious is the interaction between Metformin-repaglinide and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently after starting nilotinib and adjust the repaglinide and metformin doses. Nilotinib also prolongs the QT interval, so review other QT-active drugs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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