Drug interactions
Metformin-repaglinide + Ofloxacin
Severity: Moderate
Metformin-repaglinide and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones such as ofloxacin can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs, and severe episodes have been reported. Risk is greater in elderly and renally impaired patients.
What this interaction means in plain words
Metformin-repaglinide and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Quinolones alter pancreatic beta-cell insulin release, adding to the effect of insulin secretagogues like repaglinide.
What to do
Monitor blood glucose during the antibiotic course and counsel the patient on symptoms of dysglycemia. Switch antibiotic class if significant glucose disturbance occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Metformin-repaglinide with Ofloxacin?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones such as ofloxacin can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs, and severe episodes have been reported. Risk is greater in elderly and renally impaired patients.
How serious is the interaction between Metformin-repaglinide and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and counsel the patient on symptoms of dysglycemia. Switch antibiotic class if significant glucose disturbance occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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