Drug interactions
Metformin-repaglinide + Paroxetine
Severity: Minor
Metformin-repaglinide and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as paroxetine may enhance glucose lowering and occasionally cause hypoglycemia in patients taking antidiabetic drugs. Paroxetine may also alter glycemic control unpredictably in diabetes.
What this interaction means in plain words
Metformin-repaglinide and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Paroxetine belongs to Central Nervous System.
Why it happens
SSRIs may improve insulin sensitivity and alter glucose regulation; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping paroxetine and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metformin-repaglinide and Paroxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-repaglinide
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Paroxetine?
MediHelp rates the interaction as minor. Metformin-repaglinide and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. SSRIs such as paroxetine may enhance glucose lowering and occasionally cause hypoglycemia in patients taking antidiabetic drugs. Paroxetine may also alter glycemic control unpredictably in diabetes.
How serious is the interaction between Metformin-repaglinide and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping paroxetine and adjust antidiabetic doses if needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
