Drug interactions
Metformin-repaglinide + Pasireotide
Severity: Moderate
Metformin-repaglinide and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide frequently causes hyperglycemia by suppressing insulin and incretin secretion. This can counteract metformin and repaglinide and often requires intensified antidiabetic therapy.
What this interaction means in plain words
Metformin-repaglinide and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Pasireotide suppresses insulin secretion and incretin release, opposing the effect of antidiabetic agents.
What to do
Monitor glucose before and during pasireotide therapy and escalate antidiabetic treatment as needed, for example by adding incretin-based therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Metformin-repaglinide with Pasireotide?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide frequently causes hyperglycemia by suppressing insulin and incretin secretion. This can counteract metformin and repaglinide and often requires intensified antidiabetic therapy.
How serious is the interaction between Metformin-repaglinide and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose before and during pasireotide therapy and escalate antidiabetic treatment as needed, for example by adding incretin-based therapy.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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