Drug interactions
Metformin-repaglinide + Prednisolone
Severity: Moderate
Metformin-repaglinide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisolone raises blood glucose by increasing hepatic gluconeogenesis and peripheral insulin resistance, which opposes the effect of metformin and repaglinide. Hyperglycemia may appear or worsen, especially with higher doses or prolonged courses.
What this interaction means in plain words
Metformin-repaglinide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucocorticoid-induced insulin resistance and increased hepatic glucose output.
What to do
Monitor blood glucose closely during corticosteroid therapy and increase antidiabetic doses or add insulin if needed. Reduce the doses again as the steroid is tapered to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metformin-repaglinide and Prednisolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-repaglinide
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Prednisolone?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisolone raises blood glucose by increasing hepatic gluconeogenesis and peripheral insulin resistance, which opposes the effect of metformin and repaglinide. Hyperglycemia may appear or worsen, especially with higher doses or prolonged courses.
How serious is the interaction between Metformin-repaglinide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during corticosteroid therapy and increase antidiabetic doses or add insulin if needed. Reduce the doses again as the steroid is tapered to avoid hypoglycemia.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
