Drug interactions
Metformin-repaglinide + Primidone
Severity: Moderate
Metformin-repaglinide and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, through its metabolite phenobarbital, induces hepatic enzymes and can lower repaglinide concentrations. This may weaken glycemic control, and the effect may persist after the inducer is stopped.
What this interaction means in plain words
Metformin-repaglinide and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Primidone belongs to Central Nervous System.
Why it happens
Phenobarbital-mediated induction of CYP3A4 and CYP2C8 increases repaglinide metabolism.
What to do
Monitor blood glucose and HbA1c after starting or stopping primidone, and increase the repaglinide dose if needed. Reassess the dose when primidone is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Metformin-repaglinide with Primidone?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, through its metabolite phenobarbital, induces hepatic enzymes and can lower repaglinide concentrations. This may weaken glycemic control, and the effect may persist after the inducer is stopped.
How serious is the interaction between Metformin-repaglinide and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping primidone, and increase the repaglinide dose if needed. Reassess the dose when primidone is withdrawn.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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