Drug interactions
Metformin-repaglinide + Promethazine
Severity: Minor
Metformin-repaglinide and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine, a phenothiazine, may raise blood glucose and impair glucose tolerance, modestly reducing the effect of antidiabetic drugs.
What this interaction means in plain words
Metformin-repaglinide and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Promethazine belongs to Respiratory.
Why it happens
Phenothiazine effects on insulin secretion and sensitivity may oppose antidiabetic therapy.
What to do
Monitor blood glucose during repeated or prolonged promethazine use and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Metformin-repaglinide with Promethazine?
MediHelp rates the interaction as minor. Metformin-repaglinide and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine, a phenothiazine, may raise blood glucose and impair glucose tolerance, modestly reducing the effect of antidiabetic drugs.
How serious is the interaction between Metformin-repaglinide and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during repeated or prolonged promethazine use and adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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