Drug interactions
Metformin-repaglinide + Quinine
Severity: Minor
Metformin-repaglinide and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin and quinine are both cationic drugs handled by renal tubular secretion, and metformin may modestly raise quinine exposure. The clinical consequence is small. Quinine can also cause hypoglycemia by stimulating insulin release, which may add to repaglinide.
What this interaction means in plain words
Metformin-repaglinide and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Quinine belongs to Anti Parasitic.
Why it happens
Competition for renal tubular cationic transporters; quinine also stimulates pancreatic insulin secretion.
What to do
Check blood glucose during quinine treatment, particularly with repaglinide, and watch for quinine adverse effects such as cinchonism.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Quinine?
MediHelp rates the interaction as minor. Metformin-repaglinide and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin and quinine are both cationic drugs handled by renal tubular secretion, and metformin may modestly raise quinine exposure. The clinical consequence is small. Quinine can also cause hypoglycemia by stimulating insulin release, which may add to repaglinide.
How serious is the interaction between Metformin-repaglinide and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose during quinine treatment, particularly with repaglinide, and watch for quinine adverse effects such as cinchonism.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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