Drug interactions
Metformin-repaglinide + Ramipril
Severity: Moderate
Metformin-repaglinide and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and lower blood glucose, so hypoglycemia may occur more readily with antidiabetic agents, especially repaglinide. Renal function decline caused by ACE inhibitors may also reduce metformin clearance and raise lactic acidosis risk.
What this interaction means in plain words
Metformin-repaglinide and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Ramipril belongs to Cardiovascular.
Why it happens
Additive glucose-lowering via improved insulin sensitivity, plus possible reduced renal metformin elimination if renal function declines.
What to do
Monitor blood glucose after starting or adjusting ramipril, and check serum creatinine/eGFR periodically. Reduce or stop metformin if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Metformin-repaglinide with Ramipril?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and lower blood glucose, so hypoglycemia may occur more readily with antidiabetic agents, especially repaglinide. Renal function decline caused by ACE inhibitors may also reduce metformin clearance and raise lactic acidosis risk.
How serious is the interaction between Metformin-repaglinide and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or adjusting ramipril, and check serum creatinine/eGFR periodically. Reduce or stop metformin if renal function deteriorates.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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