Drug interactions
Metformin-repaglinide + Rifabutin
Severity: Moderate
Metformin-repaglinide and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may lower repaglinide concentrations, weakening glucose control. The effect is smaller than with rifampicin, but hyperglycemia can occur.
What this interaction means in plain words
Metformin-repaglinide and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP3A4 (and to a lesser degree CYP2C8), increasing repaglinide metabolism.
What to do
Monitor blood glucose when starting or stopping rifabutin and increase the repaglinide dose if needed. Reduce the dose again when rifabutin is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Metformin-repaglinide with Rifabutin?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and may lower repaglinide concentrations, weakening glucose control. The effect is smaller than with rifampicin, but hyperglycemia can occur.
How serious is the interaction between Metformin-repaglinide and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping rifabutin and increase the repaglinide dose if needed. Reduce the dose again when rifabutin is withdrawn.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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