Drug interactions
Metformin-repaglinide + Rufinamide
Severity: Minor
Metformin-repaglinide and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and might slightly lower repaglinide concentrations. A clinically important loss of glucose control is unlikely in most patients.
What this interaction means in plain words
Metformin-repaglinide and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Rufinamide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases repaglinide metabolism.
What to do
Check blood glucose after starting rufinamide and adjust the repaglinide dose only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Rufinamide?
MediHelp rates the interaction as minor. Metformin-repaglinide and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and might slightly lower repaglinide concentrations. A clinically important loss of glucose control is unlikely in most patients.
How serious is the interaction between Metformin-repaglinide and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose after starting rufinamide and adjust the repaglinide dose only if control worsens.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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