Drug interactions
Metformin-repaglinide + Selegiline
Severity: Minor
Metformin-repaglinide and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline, an MAO-B inhibitor, has no well-established pharmacokinetic interaction with metformin. MAO inhibitors may enhance hypoglycemic effects of antidiabetic agents, which could matter for repaglinide.
What this interaction means in plain words
Metformin-repaglinide and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
The mechanism is not well established; MAO inhibition may enhance insulin sensitivity or hypoglycemia.
What to do
Monitor blood glucose when starting or stopping selegiline and adjust antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Selegiline?
MediHelp rates the interaction as minor. Metformin-repaglinide and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selegiline, an MAO-B inhibitor, has no well-established pharmacokinetic interaction with metformin. MAO inhibitors may enhance hypoglycemic effects of antidiabetic agents, which could matter for repaglinide.
How serious is the interaction between Metformin-repaglinide and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping selegiline and adjust antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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