Drug interactions
Metformin-repaglinide + Somapacitan
Severity: Moderate
Metformin-repaglinide and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone analogs can reduce insulin sensitivity and raise glucose, which may reduce the effect of antidiabetic drugs. Growth hormone may also increase CYP-mediated clearance of some drugs.
What this interaction means in plain words
Metformin-repaglinide and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone-induced insulin resistance antagonizes antidiabetic therapy, with possible modest CYP3A4 induction.
What to do
Monitor glucose and HbA1c after starting somapacitan and increase antidiabetic doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Somapacitan?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone analogs can reduce insulin sensitivity and raise glucose, which may reduce the effect of antidiabetic drugs. Growth hormone may also increase CYP-mediated clearance of some drugs.
How serious is the interaction between Metformin-repaglinide and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting somapacitan and increase antidiabetic doses if needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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