Drug interactions
Metformin-repaglinide + Somatrogon
Severity: Moderate
Metformin-repaglinide and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon, a growth hormone analog, can reduce insulin sensitivity and raise glucose, weakening the effect of metformin and repaglinide. Higher doses carry more risk.
What this interaction means in plain words
Metformin-repaglinide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone-induced insulin resistance antagonizes antidiabetic therapy.
What to do
Monitor glucose and HbA1c after starting somatrogon and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Somatrogon?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon, a growth hormone analog, can reduce insulin sensitivity and raise glucose, weakening the effect of metformin and repaglinide. Higher doses carry more risk.
How serious is the interaction between Metformin-repaglinide and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting somatrogon and adjust antidiabetic doses as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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