Drug interactions
Metformin-repaglinide + Spironolactone
Severity: Minor
Metformin-repaglinide and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone is not a clinically established CYP2C8 inhibitor, so a meaningful increase in repaglinide exposure is unlikely. No significant interaction is expected with metformin.
What this interaction means in plain words
Metformin-repaglinide and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Spironolactone belongs to Cardiovascular.
Why it happens
Weak, unconfirmed CYP2C8 inhibition in vitro; no established clinical mechanism.
What to do
No routine adjustment is needed; monitor blood glucose as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Metformin-repaglinide with Spironolactone?
MediHelp rates the interaction as minor. Metformin-repaglinide and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Spironolactone is not a clinically established CYP2C8 inhibitor, so a meaningful increase in repaglinide exposure is unlikely. No significant interaction is expected with metformin.
How serious is the interaction between Metformin-repaglinide and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood glucose as usual.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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