Drug interactions
Metformin-repaglinide + Trandolapril
Severity: Moderate
Metformin-repaglinide and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and increase hypoglycemia risk with antidiabetic drugs. Renal function decline may also raise metformin accumulation and lactic acidosis risk.
What this interaction means in plain words
Metformin-repaglinide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Additive glucose lowering through improved insulin sensitivity, plus possible reduced metformin clearance if renal function declines.
What to do
Monitor blood glucose and renal function after starting or titrating trandolapril; reduce or stop metformin if eGFR declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Metformin-repaglinide with Trandolapril?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and increase hypoglycemia risk with antidiabetic drugs. Renal function decline may also raise metformin accumulation and lactic acidosis risk.
How serious is the interaction between Metformin-repaglinide and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function after starting or titrating trandolapril; reduce or stop metformin if eGFR declines.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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