Drug interactions
Metformin-repaglinide + Triamterene
Severity: Moderate
Metformin-repaglinide and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene and metformin are both organic cations eliminated through renal tubular secretion, so they compete for transporters. Metformin exposure may rise, and triamterene may also be affected. The clinical effect is usually modest but may matter in renal impairment.
What this interaction means in plain words
Metformin-repaglinide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Competition for renal tubular secretion via OCT2 and MATE transporters, reducing metformin clearance.
What to do
Monitor renal function and glycemic control, and watch for signs of metformin excess such as lactic acidosis in patients with reduced kidney function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Metformin-repaglinide with Triamterene?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamterene and metformin are both organic cations eliminated through renal tubular secretion, so they compete for transporters. Metformin exposure may rise, and triamterene may also be affected. The clinical effect is usually modest but may matter in renal impairment.
How serious is the interaction between Metformin-repaglinide and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glycemic control, and watch for signs of metformin excess such as lactic acidosis in patients with reduced kidney function.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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