Drug interactions
Metformin-repaglinide + Triptorelin
Severity: Minor
Metformin-repaglinide and Triptorelin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with GnRH agonists such as triptorelin can reduce insulin sensitivity and glucose tolerance, possibly worsening glycemic control.
What this interaction means in plain words
Metformin-repaglinide and Triptorelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Triptorelin belongs to Endocrine.
Why it happens
Hypogonadism induced by GnRH agonists leads to insulin resistance.
What to do
Monitor blood glucose and HbA1c during triptorelin treatment and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Triptorelin
Frequently asked questions
Can I take Metformin-repaglinide with Triptorelin?
MediHelp rates the interaction as minor. Metformin-repaglinide and Triptorelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Androgen deprivation with GnRH agonists such as triptorelin can reduce insulin sensitivity and glucose tolerance, possibly worsening glycemic control.
How serious is the interaction between Metformin-repaglinide and Triptorelin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during triptorelin treatment and adjust antidiabetic therapy if needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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