Drug interactions
Metformin-repaglinide + Valsartan
Severity: Minor
Metformin-repaglinide and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide may inhibit OATP1B1 and theoretically increase valsartan exposure, but this is unlikely to be clinically meaningful. Valsartan may slightly increase insulin sensitivity.
What this interaction means in plain words
Metformin-repaglinide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Valsartan belongs to Cardiovascular.
Why it happens
Possible OATP1B1 inhibition reducing hepatic uptake of valsartan; clinical relevance unproven.
What to do
No routine adjustment needed; monitor blood pressure and glucose as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Metformin-repaglinide with Valsartan?
MediHelp rates the interaction as minor. Metformin-repaglinide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide may inhibit OATP1B1 and theoretically increase valsartan exposure, but this is unlikely to be clinically meaningful. Valsartan may slightly increase insulin sensitivity.
How serious is the interaction between Metformin-repaglinide and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor blood pressure and glucose as usual.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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