Drug interactions
Metformin-repaglinide + Vandetanib
Severity: Moderate
Metformin-repaglinide and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits renal OCT2 uptake and may reduce metformin clearance, increasing metformin exposure. This may raise the risk of gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Metformin-repaglinide and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Vandetanib belongs to Oncology.
Why it happens
Inhibition of OCT2-mediated renal tubular secretion of metformin.
What to do
Monitor renal function and for signs of metformin toxicity. Reduce the metformin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Vandetanib?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits renal OCT2 uptake and may reduce metformin clearance, increasing metformin exposure. This may raise the risk of gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Metformin-repaglinide and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for signs of metformin toxicity. Reduce the metformin dose if adverse effects occur.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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