Drug interactions
Metformin-sitagliptin + Mifepristone
Severity: Minor
Metformin-sitagliptin and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP2C8 and CYP2C9, but neither metformin nor sitagliptin depends meaningfully on these enzymes, so no pharmacokinetic effect is expected. Mifepristone used for Cushing's syndrome may lower glucose and alter diabetes control through glucocorticoid receptor blockade.
What this interaction means in plain words
Metformin-sitagliptin and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Glucocorticoid receptor antagonism may improve glycemia; the CYP2C8/2C9 inhibition is not relevant to these drugs.
What to do
If mifepristone is given for Cushing's syndrome, monitor glucose and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Metformin-sitagliptin with Mifepristone?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP2C8 and CYP2C9, but neither metformin nor sitagliptin depends meaningfully on these enzymes, so no pharmacokinetic effect is expected. Mifepristone used for Cushing's syndrome may lower glucose and alter diabetes control through glucocorticoid receptor blockade.
How serious is the interaction between Metformin-sitagliptin and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If mifepristone is given for Cushing's syndrome, monitor glucose and adjust antidiabetic doses as needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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