Drug interactions
Metformin-sitagliptin + Procarbazine
Severity: Minor
Metformin-sitagliptin and Procarbazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting properties that may enhance insulin sensitivity and lower glucose, adding to antidiabetic drugs. The risk of significant hypoglycemia with metformin and sitagliptin is low, and the evidence is limited.
What this interaction means in plain words
Metformin-sitagliptin and Procarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-sitagliptin belongs to Endocrine; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition may enhance insulin action; the mechanism is not well established.
What to do
Monitor blood glucose during procarbazine therapy and adjust antidiabetic doses if glucose drops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Metformin-sitagliptin with Procarbazine?
MediHelp rates the interaction as minor. Metformin-sitagliptin and Procarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Procarbazine has weak MAO-inhibiting properties that may enhance insulin sensitivity and lower glucose, adding to antidiabetic drugs. The risk of significant hypoglycemia with metformin and sitagliptin is low, and the evidence is limited.
How serious is the interaction between Metformin-sitagliptin and Procarbazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during procarbazine therapy and adjust antidiabetic doses if glucose drops.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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